The safety and effectiveness of this drug hasn’t been established hinein children. It shouldn’t be used in children younger than 18 years.Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.Da wird schon so mancher davon geträumt gutschri
Patients should be cautioned that methadone, like other opioids, may produce orthostatic hypotension hinein ambulatory patients.The use of methadone hinein patients already known to have a prolonged QT interval has not been systematically studied.Teratogenic Effects. Pregnancy Category Kohlenstoff – There are no controlled studies of methadone us
Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and/or tolerance are not unusual during chronic opioid therapy.Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses